In this study efforts were made to design matrix tablet containing superporous hydrogel particles (SPHPs) for sustained delivery of Ranitidine hydrochloride. The SPHPs were prepared from superporous hydrogel of poly(AM-co-AA). The characterization studies for SPH were performed by measurement of apparent density, porosity, swelling studies, and scanning electron microscopy (SEM) studies. SEM images clearly indicated the formation of interconnected pores, and capillary channels. The SPHPs were found to be low dense, highly porous and highly swellable. The prepared tablet floated and delivered the Ranitidine hydrochloride for about 12 hour. To ascertain the kinetics of drug release, the dissolution profiles were fitted to mathematical models that include zero-order, first-order, Higuchi, Hixson-Crowell, Korsmeyer-Peppas, Weibull, and Hopfenberg. The in vitro drug release from proposed system was best explained by the Hopfenberg model indicating that the release of drug from tablets displayed heterogeneous erosion. It is concluded that the proposed gastroretentive drug-delivery system based on SPHPs is promising for stomach specific delivery of Ranitidine hydrochloride.
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